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Toxicological Significance of Bioactive Compounds of Plant Origin


Pharmacognosy Communications,2021,11,2,67-77.
Published:April 2021
Type:Review Article

Toxicological Significance of Bioactive Compounds of Plant Origin

Franklyn Okechukwu Ohiagu1, Paul Chidoka Chikezie1,*, Chinwendu Maureen Chikezie2

1Department of Biochemistry, Imo State University, Owerri, NIGERIA.

2Department of Biochemistry, Federal University of Technology, Owerri, NIGERIA.


Aim/Background: The evaluation of toxicological significance of medicinal plants is necessary prior to their use for drug development or for the purpose of improving the therapeutic efficacy of existing therapies. Regrettably, there is little information on the toxicity profiles of the chemical constituents of commonly used medicinal plants. Meanwhile, available information on the toxicity concerns of the use of medicinal plants are often taken for granted and ignored. Materials and Methods: The information and data used in this review report were sourced from scientific databases such as Google Scholar, PubMed, SpringerLink, Medline, ScienceDirect, and Mendeley. Results: The noxious chemical compounds in plants may be neurotoxic, mutagenic or cytotoxic. They may disrupt metabolic processes in living organisms and adversely affect the skin and the mucosal tissues, etc. It is noteworthy that the beneficial as well as the toxicological outcomes following the use of plant materials depends on the chemical nature of their constituent bioactive compounds. Conclusion: Plants, especially those used for ethnomedicinal purposes, contain significant amounts of noxious bioactive compounds, which may elicit adverse health effects on both humans and other animals. The isolation and purification of plant bioactive compounds for toxicological evaluation prior to their usage in the development of pharmaceutical formulations is recommended.

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Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

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Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
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