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Toxicological Significance of Bioactive Compounds of Plant Origin

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Abstract
Pharmacognosy Communications,2021,11,2,67-77.
Published:April 2021
Type:Review Article

Toxicological Significance of Bioactive Compounds of Plant Origin

Franklyn Okechukwu Ohiagu1, Paul Chidoka Chikezie1,*, Chinwendu Maureen Chikezie2

1Department of Biochemistry, Imo State University, Owerri, NIGERIA.

2Department of Biochemistry, Federal University of Technology, Owerri, NIGERIA.

Abstract:

Aim/Background: The evaluation of toxicological significance of medicinal plants is necessary prior to their use for drug development or for the purpose of improving the therapeutic efficacy of existing therapies. Regrettably, there is little information on the toxicity profiles of the chemical constituents of commonly used medicinal plants. Meanwhile, available information on the toxicity concerns of the use of medicinal plants are often taken for granted and ignored. Materials and Methods: The information and data used in this review report were sourced from scientific databases such as Google Scholar, PubMed, SpringerLink, Medline, ScienceDirect, and Mendeley. Results: The noxious chemical compounds in plants may be neurotoxic, mutagenic or cytotoxic. They may disrupt metabolic processes in living organisms and adversely affect the skin and the mucosal tissues, etc. It is noteworthy that the beneficial as well as the toxicological outcomes following the use of plant materials depends on the chemical nature of their constituent bioactive compounds. Conclusion: Plants, especially those used for ethnomedicinal purposes, contain significant amounts of noxious bioactive compounds, which may elicit adverse health effects on both humans and other animals. The isolation and purification of plant bioactive compounds for toxicological evaluation prior to their usage in the development of pharmaceutical formulations is recommended.

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Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs.

Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

The journal aims to cater the latest outstanding developments in the field of pharmacognosy and natural products and drug design covering but not limited to the following topics:

  • Pharmacognosy and pharmacognistic investigations
  • Research based ethnopharmacological evaluations
  • Biological evaluation of crude extracts, essential oils and pure isolates
  • Natural product discovery and evaluation
  • Mechanistic studies
  • Method and technique development and evaluation
  • Isolation, identification and structural elucidation of natural products
  • Synthesis and transformation studies

Distinctions:  The most widely read, cited, and known Pharmacognosy Communications and website is well browsed with all the articles published. More than 20,000 readers in nearly every country in the world each month

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Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
ISSN :2249-0159 (Print) ; 2249-0167 (Online) Frequency : Quarterly Rapid at a time publication (4 issues/year)

Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online  publication is 45 days.
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