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Kunzea ambigua (Sm.) Druce and Kunzea flavescens C.T. White and W.D. Francis Essential Oils Inhibit the Growth of Some Bacterial Triggers of Inflammatory Diseases

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Abstract
Pharmacognosy Communications,2021,11,2,81-87.
Published:April 2021
Type:Original Article

Kunzea ambigua (Sm.) Druce and Kunzea flavescens C.T. White and W.D. Francis Essential Oils Inhibit the Growth of Some Bacterial Triggers of Inflammatory Diseases

Célia Barillot1,2, Ian Edwin Cock1,3,*

1Environmental Futures Research Institute, Griffith University, Brisbane, AUSTRALIA.

2School of Biology, Ecole de Biologie Industrielle (EBI), Cergy, FRANCE.

3School of Environment and Science, Griffith University, Brisbane, AUSTRALIA.

Abstract:

Introduction: Kunzea ambigua (Sm.) Druce and Kunzea flavescens C.T. White and W.D. Francis are endemic Australian plants. Decoctions, infusions and essential oils produced from the leaves were used traditionally to treat a variety of bacterial diseases. Despite this, these species have not been rigorously examined for antibacterial properties against many pathogens. Methods: The antimicrobial activity of K. ambigua and K. flavescens essential oils and a K. ambigua hydrosol was investigated by disc diffusion and liquid dilution MIC assays against a panel of pathogenic bacteria. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: K. ambigua and K. flavescens essential oils displayed noteworthy growth inhibitory activity against A. baylyi, K. pneumonia, P. mirabilis and P. aeruginosa (MIC values substantially <1000μg/mL). Indeed, MIC values as low as 33μg/mL were noted against P. aeruginosa. Noteworthy growth inhibitory activity was also noted for the K. ambigua hydrosol against A. baylyi and P. aeruginosa. All extracts were determined to be non-toxic in the Artemia franciscana nauplii bioassay, indicating their safety for internal use as well as for topical uses. Conclusion: The lack of toxicity of the Kunzea spp. extracts and their growth inhibitory bioactivity against a panel of pathogenic bacteria partially validate the traditional usage of these species to treat bacterial diseases and indicate their potential in the development of antiseptic agents.

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Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

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Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
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