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Kunzea ambigua (Sm.) Druce and Kunzea flavescens C.T. White and W.D. Francis Essential Oils Inhibit the Growth of Some Bacterial Triggers of Inflammatory Diseases

Célia Barillot1,2, Ian Edwin Cock1,3,*

1Environmental Futures Research Institute, Griffith University, Brisbane, AUSTRALIA.

2School of Biology, Ecole de Biologie Industrielle (EBI), Cergy, FRANCE.

3School of Environment and Science, Griffith University, Brisbane, AUSTRALIA.

Pharmacognosy Communications,2021,11,2,81-87.
DOI:10.5530/pc.2021.2.17
Published:April 2021
Type:Original Article

ABSTRACT

Introduction: Kunzea ambigua (Sm.) Druce and Kunzea flavescens C.T. White and W.D. Francis are endemic Australian plants. Decoctions, infusions and essential oils produced from the leaves were used traditionally to treat a variety of bacterial diseases. Despite this, these species have not been rigorously examined for antibacterial properties against many pathogens. Methods: The antimicrobial activity of K. ambigua and K. flavescens essential oils and a K. ambigua hydrosol was investigated by disc diffusion and liquid dilution MIC assays against a panel of pathogenic bacteria. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: K. ambigua and K. flavescens essential oils displayed noteworthy growth inhibitory activity against A. baylyi, K. pneumonia, P. mirabilis and P. aeruginosa (MIC values substantially <1000μg/mL). Indeed, MIC values as low as 33μg/mL were noted against P. aeruginosa. Noteworthy growth inhibitory activity was also noted for the K. ambigua hydrosol against A. baylyi and P. aeruginosa. All extracts were determined to be non-toxic in the Artemia franciscana nauplii bioassay, indicating their safety for internal use as well as for topical uses. Conclusion: The lack of toxicity of the Kunzea spp. extracts and their growth inhibitory bioactivity against a panel of pathogenic bacteria partially validate the traditional usage of these species to treat bacterial diseases and indicate their potential in the development of antiseptic agents.

Key words: Ankylosing spondylitis, Antibacterial activity, Australian plants, Multiple sclerosis, Myrtaceae, rheumatoid arthritis, Tick bush, White Kunzea
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