Phytochemical Composition and Potential Genotoxic effects of Important Egyptian Medicinal Plants

groupview

Abstract
Pharmacognosy Communications,2015,5,3,207-216.
Published:16th June 2015
Type:Original Article

Phytochemical Composition and Potential Genotoxic effects of Important Egyptian Medicinal Plants

Khaled Rashed1, Roel Anthonissen2, Davie Cappoen2 and Luc Verschaeve2,3

1Pharmacognosy Department, National Research Centre, Dokki, Giza, Egypt.

2Operational directorate Food, Medicines and Consumer Safety, Toxicology Unit, Scientific Institute of Public Health, Brussels, Belgium.

3Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

Abstract:

Introduction: We performed a phytochemical analysis and investigated the potential genotoxic properties of ten different methanol extracts of plants that are frequently used in Egypt for medicinal purposes. Such studies are important because these plants were never thoroughly investigated with respect to their possible potential sideeffects and risks for humans. Materials and Methods: In this study we used the bacterial Vitotox test and alkaline comet assay in human C3A cells to estimate their genotoxic potential. The Vitotox test is an interesting screening test which correlates very well with the well-known Ames assay but has the advantage of being rapid, sensitive and requiring only small amounts of a test compound. The test was conducted in the presence and absence of a metabolizing S9-enzyme fraction. The comet assay is now a widely used and validated genotoxicity test which can be applied in all DNA-containing cells. In this study it was conducted in human C3A cells which conserved phase I and II biotransformation capabilities. The in vitro NRU assay was used to investigate toxicity and utilized as a dose-finding test. Results: None of the plants have shown genotoxic properties although one of them, Derris rubusta, showed borderline genotoxicity in both tests. This plant also contains alkaloids and coumarins, besides flavonoids, carbohydrates, tannins and triterpenes that were also found in the other plants. Conclusion: So far all 10 investigated medicinal plants appeared not genotoxic but due to borderline effects, Derris robusta deserves further complementary investigations.

Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs.

Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

The journal aims to cater the latest outstanding developments in the field of pharmacognosy and natural products and drug design covering but not limited to the following topics:

  • Pharmacognosy and pharmacognistic investigations
  • Research based ethnopharmacological evaluations
  • Biological evaluation of crude extracts, essential oils and pure isolates
  • Natural product discovery and evaluation
  • Mechanistic studies
  • Method and technique development and evaluation
  • Isolation, identification and structural elucidation of natural products
  • Synthesis and transformation studies

Distinctions:  The most widely read, cited, and known Pharmacognosy Communications and website is well browsed with all the articles published. More than 20,000 readers in nearly every country in the world each month

Aim and Scope | Editorial Board | Indexed & Abstracted | Instruction to Authors | Manuscript Submission & Charges

Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
ISSN :2249-0159 (Print) ; 2249-0167 (Online) Frequency : Quarterly Rapid at a time publication (4 issues/year)

Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online  publication is 45 days.
Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.